Description
SELANK 10MG :
| Unit Size | 10 mg/ vial |
| Unit Quantity | 1 vial |
| Purity (Mass Spectrometry & UV) | 99.54% |
| Sequence | H-Thr-Lys-Pro-Arg-Pro-Gly-Pro-OH |
| Molecular Formula | C33H57N11O9 |
| Appearance | Lyophilized White Powder |
| Source | Chemical Synthesis |
| Storage | Lyophilized Selank is stable at room Temperature for 90 days, however it is best to store in a freezer below – 8c for any extended |
| Terms | The products we offer are intended for laboratory research use only. Please familiarize yourself with our terms of service prior to ordering. |
Selank 10mg
View Research Overview & References
Selank is a synthetic peptide analog of the natural human protein tuftsin, designed exclusively for in vitro laboratory research. Tuftsin, first identified at Tufts University in 1983, is a tetrapeptide derived from the Fc-domain of immunoglobulin (Ig) G. It plays a significant role in immunomodulation by participating in antigen processing, the formation of reactive oxygen species, and the development of antigen complexes.1,2
Selank mimics tuftsin but includes an additional three amino acids at the C-terminus (Pro-Gly-Pro), which enhances its stability and half-life for experimental research.3
Development and Mechanism of Action
Selank was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences.4 Research suggests that Selank influences the expression of genes involved in GABAergic neurotransmission and increases the concentrations of monoamine neurotransmitters in experimental animal models.3,4
Research Findings: Cytokine Modulation and Stress Response
In laboratory studies, Selank demonstrated the ability to modulate cytokine expression. Specifically, it reduced levels of IL-6 and IL-1beta while normalizing IL-4 levels under conditions of social stress in animal models.5 These findings highlight Selank’s relevance for research into modulation of stress-related cytokine responses and immune signaling in controlled research environments.
Cognitive Function Research
Selank has also been studied in animal models for effects related to learning and memory. Although these effects are limited to in vitro and animal studies, researchers have reported findings related to cognitive function measures in these models.6,7
Important Safety Information
Selank is intended strictly for research purposes only. It is not approved for human or animal consumption, medical treatment, or therapeutic use. All research involving this peptide must comply with laboratory safety protocols and be conducted by qualified personnel in controlled research settings only.
Product Information
- Form: Lyophilized white powder
- Intended Use: In vitro research only
References
1. Fridkin M, Najjar VA. Tuftsin: Its Chemistry, Biology, and Clinical Potential. Crit Rev Biochem Mol Biol. 1989;24:1-40.
2. Najjar VA. Tuftsin, a natural activator of phagocyte cells: An overview. Ann N Y Acad Sci. 1983:1-11.
3. Volkova A, Shadrina M, Kolomin T, Andreeva L, et al. Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission. Front Pharmacol. 2016;7:31.
4. Filatova E, Kasian A, Kolomin T, Rybalkina E, et al. GABA, Selank, and Olanzapine Affect Gene Expression in IMR-32 Cells. Front Pharmacol. 2017;8:89.
5. Leonidovna YA, et al. The Influence of Selank on Cytokine Levels Under Social Stress. Curr Rev Clin Exp Pharmacol. 2021;16(2):162-167.
6. Narkevich VB, et al. Effects of Heptapeptide Selank on Brain Monoamines in Mice. Eksp Klin Farmakol. 2008;71(5):8-12.
7. Sokolov OY, et al. Effects of Selank on Behavioral Reactions in Mice. Bull Exp Biol Med. 2002;133(2):133-5.
