Description
FRAGMENT 176-191 5mg :
| Unit Size | 5 mg/vial |
| Unit Quantity | 1 vial |
| Purity (Mass Spectrometry and UV) | 99.56% |
| Sequence | H-Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe-OH |
| Molecular Formula | C78H123N23O23S2 |
| Appearance | Lyophilized White Powder |
| Source | Chemical Synthesis |
| Storage | Lyophilized FRAGMENT 176-191 is stable at room Temperature for 90 days, however it is best to storer in a freeze below – 8c for any extended period of time. |
| Terms | The products we offer are intended for laboratory research use only. Please familiarize yourself with our terms of service prior to ordering. |
FRAGMENT 176-191 5mg
View Research Overview & References
Fragment 176-191 is a synthetic peptide analog of human growth hormone (hGH) with a molecular weight of 1812 g/mol. This peptide consists of 16 amino acids from the C-terminus of hGH, spanning positions 176 to 191, and includes a substitution of tyrosine to phenylalanine at position 191, a modification studied for its effects on lipid metabolism pathways.1 Functionally, Fragment 176-191 is studied for its interaction with pituitary receptors relevant to growth hormone-releasing hormone (GHRH) signaling pathways.2
Lipid Metabolism Research
Fragment 176-191 has demonstrated lipolytic activity in laboratory studies. In a genetically engineered mouse model with increased fat stores, the peptide was associated with increased fat breakdown. This effect was absent in mice lacking the beta-3 adrenergic receptor (ADRB3), indicating that this activity is mediated through this receptor in the animal model studied.3 Additional research has examined the peptide’s effects on thermogenesis markers in skeletal muscle in animal models.
Glucose and Insulin Signaling Research
Animal studies have examined Fragment 176-191’s effects on insulin secretion and blood glucose markers.4 These are preliminary laboratory findings in animal models and do not establish safety, efficacy, or suitability for any human or animal application.
Product Information
Fragment 176-191 is supplied as a lyophilized white powder at a concentration of 5 mg/vial.
Important Notice
This product is intended for in vitro and in vivo (animal) laboratory research use only. It is not approved for human or veterinary use under any circumstances, and has not been evaluated for safety or efficacy in humans or animals.
References
1. Harvey S, Martinez-Moreno CG. Growth Hormone: Therapeutic Possibilities—An Overview. Int J Mol Sci. 2018;19(7):2015.
2. Heffernan M, Summers RJ, Thorburn A, et al. The Effects of Human GH and Its Lipolytic Fragment (AOD9604) on Lipid Metabolism Following Chronic Treatment in Obese Mice and β3-AR Knock-Out Mice. Endocrinology. 2001;142(12):5182-9.
3. Ng FM, Bornstein J. Hyperglycemic Action of Synthetic C-Terminal Fragments of Human Growth Hormone. Am J Physiol. 1978;234(5):E521-6.
4. Kwon DR, Park GY. Effect of Intra-Articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model. Ann Clin Lab Sci. 2015;45(4):426-32.
